Sunday, July 30, 2006

Alternative med acquittal cheered

http://calsun.canoe.ca/News/Alberta/2006/07/29/1708897-sun.html

By BILL LAYE, CALGARY SUN
Two southern Alberta men charged with violating federal health regulations say their acquittal in provincial court yesterday bodes well for alternative medicine in Canada.
And while Judge Gerald Meagher stopped short of calling Health Canada's prosecution of their case high-handed, Synergy Group Canada principals Tony Stephan and David Hardy said they will be looking at having the federal agency investigated.
The pair had been charged in 2004 with selling their Truehope nutritional supplement -- billed as a treatment for depression and bipolar disorder -- without a federal Drug Identification Number (DIN) a year earlier.
But in handing down his decision to a packed courtroom, Meagher said he accepted defence arguments they made every effort they could in meeting that requirement during a time when the rules regarding alternative treatments were being rewritten.
During the three-week trial, Harvard psychiatrist Dr. Charles Popper testified injuries and suicides were a distinct possibility for those who could no longer receive the treatment, the judge noted.
"The evidence presented by the defence was clear and compelling," Meagher said. "The defendants obviously felt compelled to disobey the DIN requirements."
The Crown's case was further undermined by the fact the men were finally granted executive clearance to legally sell their product in March 2004 -- shortly after Pierre Pettigrew became health minister -- and that order still stands, Meagher said.
The pair, based in Raymond, about 250 km southeast of Calgary, said they're hoping the verdict will help open the door for more research into other non-traditional medical treatments across the country -- and they want Health Canada investigated by the RCMP.

Wednesday, July 26, 2006

Research Finds Little Proof on Menopause Treatments

http://www.nytimes.com/2006/07/25/health/25meno.html?_r=1&ref=health&oref=slogin

By NICHOLAS BAKALAR
Almost half of American women seek alternative or complementary treatments for the unpleasant symptoms of menopause. But a systematic review of the evidence has found little proof that any of them work.
Researchers reviewed 70 randomized controlled trials of alternative treatments and found insufficient scientific evidence to support the effectiveness of any of the commonly used remedies: herbs, mind-body techniques, energy therapies using magnets or electrical nerve stimulation, homeopathy, naturopathy or culturally based non-Western medical treatments. The review was published yesterday in The Archives of Internal Medicine.
Most of the studies were of poor quality, but even those judged by the researchers to be “fair” or “good” on a three-point scale most often demonstrated little difference between alternative treatments and placebo. For example, a study that compared 56 patients given a soy drink with 55 who drank a medically inactive liquid found no difference between the groups, although both groups got some symptom relief.
Three of four trials of the herb black cohosh, a common alternative treatment for menopausal symptoms, showed no improvement, but the studies suffered from poor methodology. The fourth, judged “fair” by the researchers, enrolled 304 women, half of whom took black cohosh and the other half a placebo for 12 weeks. Compared with placebo, there was greater improvement in the treatment group as measured by the participants’ own reports. Dr. Anne Nedrow, the lead author of the review, said the study “did show some benefits, but we had to balance it with studies that showed none.”
The scientists examined nine studies of mind-body therapies, treatments that focus on the ways in which emotional, mental, social, spiritual and behavioral factors can affect health. While they varied considerably in quality, none found a significant improvement compared with placebo treatment using stress-management techniques, meditation, relaxation exercises, audiotape relaxation or supportive counseling.
Therapies involving reflexology, bone manipulation and magnetic devices were found to be almost completely useless. In one small study of magnets, the placebo group showed more improvement than the group that received the magnet treatment.
Acupuncture was also ineffective. The reviewers examined four trials; three demonstrated no difference between real and sham procedures. The fourth, judged by the reviewers to be of fair quality, compared standard estrogen therapy, sham acupuncture and electroacupuncture, a variation on the practice in which continuous electrical pulses are delivered through the needles. Only the estrogen group improved.
None of six trials of traditional Chinese medicinal herbs, three using a combination of medicines, showed a significant benefit over controls for menopausal symptoms.
Studies of biological therapies like kava, primrose oil, guar gum, wild yam cream and red clover showed little or no difference in symptoms between those who used the substances and those given a placebo.
Still, Dr. Nedrow said, “We don’t have proof these therapies don’t work, either, because the studies are not of the length, quality and size that you can draw those conclusions.” Dr. Nedrow is an assistant professor of medicine at the Oregon Health and Science University.
Most of the trials lacked consistent or clear reporting of adverse effects, although one five-year follow-up study of soy indicated that it increased the risk for endometrial hyperplasia, a usually benign thickening of the lining of the uterus that can cause abnormal bleeding. Liver toxicity has been reported with both black cohosh and kava.
Dr. Nedrow is not opposed to her patients’ using these treatments.
“I think the placebo is a powerful thing and underutilized,” she said. “If they’re taking a product and they like it and it is safe, I say great, and I won’t spend the time to read my article to them.”
And she added, “I think that some of these treatments, if the research was better, might show benefits.”

Judge lifts orders in teen's case

http://www.timesdispatch.com/servlet/Satellite?pagename=RTD/MGArticle/RTD_BasicArticle&c=MGArticle&cid=1149189600372&path=!news&s=1045855934842

Cancer patient doesn't have to report to hospital; trial set next month to settle dispute
BY SHAUN BISHOP
TIMES-DISPATCH STAFF WRITER
Wednesday, July 26, 2006
ACCOMAC -- A Chincoteague teenager's fight to use alternative medicine to treat his cancer will get another chance after a judge suspended an earlier ruling forcing him to undergo traditional treatment.
"This is the best moment that I've ever felt in my life. I feel so happy," Starchild Abraham Cherrix, 16, said outside the courthouse.
"Now I'm feeling free, I'm feeling like I have my rights back and I'm feeling like I'm in America once again," said the teen who has said conventional treatment made him so ill he never wants to go through it again.
Attorneys representing the Cherrix family said the eventual outcome of the case could have broad implications for the decision-making powers of parents in Virginia.
"This is a huge victory for this family, but as far as we're concerned, this is a huge victory for all Virginians," said John Stepanovich, an attorney for Cherrix's parents, Jay and Rose Cherrix, who support their son's decision.
In a hearing yesterday, Accomack Circuit Judge Glen Allen Tyler suspended two key judgments the Accomack Juvenile and Domestic Relations District Court made in the case last week. As a result:
Cherrix did not have to go to a Norfolk hospital yesterday afternoon and submit to tests and treatment prescribed by doctors, as ordered last Friday by the juvenile court.
His parents regained custody of their son. The juvenile court had given partial custody to the county's Department of Social Services, which supported requiring him to undergo the hospital treatment.
It was an emotional victory for the Cherrix family, which has been fighting to allow Abraham to use an organic diet and herbal supplements as treatment for Hodgkin's disease, a cancer of the lymph nodes.
The teen's case began after he sought the alternative remedy under advisement from a clinic in Mexico when the cancer returned in February. He had gone through chemotherapy when the cancer was first discovered a year ago.
After his case was reported to the local Department of Social Services, Juvenile Court Judge Jesse E. Demps ruled last Friday that Cherrix would have to undergo treatment at Children's Hospital of the King's Daughters in Norfolk yesterday afternoon and ordered his parents to consent to the doctors' orders.
Jay and Rose Cherrix appealed the rulings on Monday and were granted yester- day's hearing.
"I felt like we had Abraham back and we were a family again," said Jay Cherrix, his father.
Virginia Attorney General Bob McDonnell also filed a brief in the circuit court supporting the family's request to stay the juvenile-court judge's rulings. McDonnell filed a similar brief in juvenile court during their appeal Monday.
Tyler set the trial date for Aug. 16 in Accomack Circuit Court to decide whether the social-services department can force the teen to undergo conventional cancer treatment.
Attorneys for the Cherrixes said they plan to present expert witnesses, including clinicians from the Mexico clinic that is supervising Abraham's treatment.
"It's being portrayed out there that he's just sort of waiting around on his deathbed," Stepanovich said. "He's under a treatment that he chose . . . and he's doing great."
The case has attracted national media attention as Cherrix has appeared on CNN and NBC's "Today" show, among other programs.
In court yesterday, Stepanovich said going to the hospital for chemotherapy would do irreparable, irreversible harm to Cherrix and would essentially render moot the family's right to appeal the order that he receive hospital treatment.
Carl Bundick, a lawyer from the Department of Social Services, agreed that a stay would be appropriate given the circumstances, but urged the judge to schedule another hearing promptly.
"We're wanting the child to be treated appropriately," Bundick said.
A juvenile-court hearing two weeks ago was closed to the public, but Tyler said yesterday that since the family had been discussing the case with the media, he did not see a reason the Aug. 16 trial should be closed.
Abraham Cherrix said he remains confident that he will get a favorable ruling, and he believes people around the nation are watching and hoping for a similar outcome.
"This could happen to anyone," he said. "This is something the government can do, and you've got to let people know this can't happen."
Contact staff writer Shaun Bishop at sbishop@timesdispatch.com or (804) 649-6578.

Monday, July 24, 2006

Virginia Teen Forced To Undergo Chemotherapy

http://www.wric.com/Global/story.asp?S=5187442&nav=menu28_2

July 24, 2006, 08:08 AM EDT
A Virginia teenager plans to fight a court order preventing him from using alternative medicine to battle his cancer.
An attorney for 16-year-old Abraham Cherrix and his parents says they are devastated by Friday's court ruling but they plan to file an appeal today.
The ruling says the teen's parents must consent to a hospital staff's prescribed treatment for their son's Hodgkin's Disease. That treatment is chemotherapy. On Friday, a judge found Abraham's parents negligent for allowing their son to pursue an alternative treatment from Mexico consisting of a sugar-free organic diet and herbal supplements. The court order requires the parents take Abraham for treatment to Children's Hospital of the King's Daughters in Norfolk by 1pm Tuesday. The family's attorney plans to ask a higher court to stay it's enforcement of that part of the order while they appeal.
The prescribed treatment, chemotherapy, is one Abraham says he can't endure again.
"The chemo, the tests...no it's just too much for me. I am not going to go through with that again," he says.
Another option for Cherrix is to seek emancipation from his parents, making him legally an adult, who could then decide for himself. But the issue may be time. Cherrix cancer has already reached stage three

Acupuncture Can Help Clear A Chronic Pain In The Neck

http://www.medicalnewstoday.com/medicalnews.php?newsid=47672&nfid=rssfeeds

22 Jul 2006 There is moderate evidence that acupuncture can relieve chronic neck pain. Between 26 - 71 percent of the adult population claims to have had at least one episode of neck pain or stiffness during their life. In many cases, this can last for months and has a large impact on life style, work and health care expenditure. Acupuncture is one of the complementary medicines that is frequently used. A group of Canadian-led Cochrane Review Authors completed a systematic review of the research literature to see whether there is evidence that it works. They found 10 trials, with a total of 661 participants, which investigated whether acupuncture alleviated neck pain. In nine of the trials, participants had suffered neck pain for three or more months, while one included people who had had pain for at least six weeks. To assess whether acupuncture reduces pain at all, some trials compared acupuncture with "sham" or "placebo" treatments. In other trials, the researchers were trying to see how well acupuncture worked compared to another treatment. Overall, people who received acupuncture reported better pain relief immediately after treatment than those who received sham treatments such as TENS or laser that had the machines switched off, or acupuncture with the needles inserted in the wrong place. People who had acupuncture also reported that their pain went away to a greater extent than those who were just on a list waiting for treatment. In one small trial, people who received acupuncture reported better pain relief in the short-term than those who received massage therapy. There were no serious side effects reported in any of these trials. "What we need now are some trials that include greater numbers of people and look at the long-term effect of the treatment," says lead Review Author Dr Kien Trinh who works in McMaster University, Hamilton, Canada. Review Title: Trinh KV et al. Acupuncture for neck disorders. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004870. ### There are also several programs, such as the Health InterNetwork Access to Research Initiative (HINARI) that provide access in developing countries. To find out whether your country is included in any of these programmes/provisions, or to learn how to get access if you don't already have it, please visit: http://www.thecochranelibrary.com/. Jadad AR, Cook DJ, Jones A, Klassen TP, Tugwell P, Moher M, et al. Methodology and reports of systematic Reviews and meta-analysies: a comparison of Cochrane Reviews with articles published in paper-based journal. About Wiley InterScience Since its commercial launch in January 1999, Wiley InterScience (http://www.interscience.wiley.com/) has built on its reputation as a world-leading Internet resource for quality research material promoting discovery across the spectrum of scientific, technical, medical and professional endeavors by continuously adding new content and functionality, offering sophisticated search and navigation capabilities, and providing robust online manuscript submission and management tools. Today Wiley InterScience features a vast resource of must-have content from more than 2,500 journals, books, reference works, databases, laboratory manuals and the Cochrane Library, which is the world's best-known resource for evidence-based medicine. More than half of Wiley's journals on Wiley InterScience are digitized back to Volume 1, Issue 1 as part of the development of the Wiley InterScience backfile collection. When it is completed by 2007, in conjunction with Wiley's Bicentennial, it will be one of the largest archives of its kind issued by a single publisher, with content dating back to 1799 and more than 950,000 articles of scientific and scholarly research. About John Wiley & Sons, Inc. Founded in 1807, John Wiley & Sons, Inc., provides must-have content and services to customers worldwide. Our core businesses include scientific, technical, and medical journals, encyclopedias, books, and online products and services; professional and consumer books and subscription services; and educational materials for undergraduate and graduate students and lifelong learners. Wiley has publishing, marketing, and distribution centers in the United States, Canada, Europe, Asia, and Australia. The company is listed on the New York Stock Exchange under the symbols JWa and JWb. Wiley's Internet site can be accessed at http://www.wiley.com/. Contact: Amy Molnar John Wiley & Sons, Inc.
Article URL: http://www.medicalnewstoday.com/medicalnews.php?newsid=47672

Nothing can cure you

http://www.timesonline.co.uk/article/0,,8125-2278807,00.html

The placebo effect is powerful, so why aren’t we testing and using it? Toby Murcott finds the catch
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Imagine a future in which NHS doctors and nurses have been given free rein to use dummy tablets and therapies on patients. It would be a future in which the power of placebos — inactive treatments that make patients feel better through expectation — was officially recognised.
A placebo-development race begins among the leading drug companies, which spend millions finding the exact shade of blue, white or pink sugar pill that inspires most confidence in the patient. The pharmacist oozes optimism about your future health as he hands you the package of pills. “Trust me. This will help you,” he says. And it probably will, because placebos do help people get better.
The scenario is, of course, ridiculous. It would mean pharmaceutical companies being given, in effect, a licence to produce snake oil. And doctors, nurses and pharmacists would effectively con patients to try to make them feel better.
But the fact is that the placebo is powerful. Four years ago, a big study examined two popular treatments for depression: the herbal remedy St John’s Wort, the antidepressant tablet Zoloft, and a placebo. It revealed, amazingly, that the placebo was more effective than both of them.
Though they may be unwilling to admit it, doctors and their treatments often owe at least some of their success to the placebo. Just the reassurance of a consultation with your doctor can be enough. Complementary therapists, however, are often explicit about the placebo effect as one of their main tools. Spending time listening to patients and offering support and sympathy is one of the reasons given for the success of complementary therapies, rather than the efficacy of the actual treatments.
As a science writer and scientist, the full implications of this began to hit me as I researched my book The Whole Story, investigating the power of complementary therapy. I realised that the placebo, while being at the heart of why many complementary therapies work, is also the root cause of why they should never be made freely available on the NHS unless they can be shown to be more than a placebo.
My voyage of discovery began in Bristol, in summer 2004. I was interviewing Professor Paul Dieppe, a consultant rheumatologist and Professor of Health Services Research at Bristol University. He was adamant that complementary medicine should be wary of seeking orthodox approval, a position I found striking from an established and respected doctor. He argued that if complementary therapists sought recognition and approval by the medical establishment then this would compromise the benefits of the treatments they practised.
His comments puzzled me at the time, but I came to appreciate their wisdom. First, he was saying that as soon as you seek orthodox approval for unorthodox approaches, you have to be open about the operation of the placebo effect. And once everyone knows that a treatment works through a sophisticated form of deception, the power of the placebo dissipates.
Secondly, he was saying that in a head-to-head with conventional medicines, complementary medicines are bound to come off worse, so it’s not worth even trying to compete on the same ground. It’s all about the techniques used to test treatments before doctors can prescribe them.
The gold standard of clinical research is the double-blind randomised controlled trial. It’s the best way we have of testing whether a treatment works, but it’s not good at testing treatments that aren’t pharmaceuticals. One reason for this is that during the trials, half of the patients receive the new treatment, and half receive a dummy pill (placebo). It is vital that neither group knows which they are getting, and that the practitioner doesn’t know which treatment he is giving (ie, double-blind). But with psychiatry, shiatsu, reiki, laying on of hands, physiotherapy and many others, it is impossible for the therapist to give a dummy treatment and for the patient or the therapists not to know it, as they can see or feel that it’s different (unlike with pills).
Another reason that complementary therapies are difficult to tackle with double-blind randomised controlled trials is that the treatment is invariably accompanied by elements of lifestyle change and emotional support from the therapist. Clinical trials try to cancel out all these “external” differences to measure the effect of the treatment alone, so all other benefits go unrecorded.
This last point was brought home to me at a conference on complementary therapy that I attended at Southampton University in 2004. At lunch I met a PhD student, John Hughes, who was conducting social scientific research into why some arthritis patients went to see an acupuncturist. What he found was that some people said that while the needles did nothing for the pain, the treatment made them feel more able to live their lives.
In other words, complementary treatments can work in a complex, multifaceted way, in which inspiring the confidence of the patient (the placebo) is an intrinsic part. Clinical trials do not reflect this. To assess complementary therapies properly, we need to find new ways of assessing them that measure this complexity; double-blind randomised controlled trials will never do it. This is not to say that there should not be rigorous testing, and this is particularly true of herbal medicines — such as black cohosh, which this week was the subject of a warning from the medicines regulatory agency because of a link to liver disorders.
But it does leave us with a dilemma. By testing complementary therapies using the best means we have — double-blind randomised controlled trials — we diminish them. In fact, treatments that aren’t pharmaceuticals tend either not to get this high quality trialling, or to come out of it rather badly — in which case they inevitably receive a public battering.
But unless we test them thoroughly, and find them to be effective, there can be no justification for introducing them into the NHS. If we allowed state-sponsored administration of treatments that have little more backing them than the power of placebo, it would be open season, with every elixir-pusher provided with a new legitimacy. The power of placebo lands complementary therapy in a Catch-22 situation.
Complementary medicines help many people, and we need to recognise that the power of the placebo is their strength, rather than their weakness. But until we agree a better way of testing treatments, it is best that the complementary remains exactly that — available separately and privately, and not even trying to compete with the medical big boys.
The Whole Story, by Toby Murcott (published by Macmillan in paperback, July 20, £8.99), is available from Books First for £8.54, free p&p. Call 0870 1608080, or visit www.timesonline.co.uk/booksfirstbuy

Bladder cancer case shows need to regulate herbal remedies

http://www.cbc.ca/story/science/national/2006/07/21/herbal-warning.html?ref=rss

Last Updated Fri, 21 Jul 2006 16:20:23 EDT
CBC News
The case of a man who developed cancer after taking a Chinese liver tonic highlights the dangers of unregulated herbal therapies, British doctors say.
A 30-year-old Chinese man was referred to a kidney clinic at London's Whittington Hospital in 2003 after showing blood in his urine.
The man had been taking the Chinese herb Longdan Xieganwan to "enhance" his liver, Dr. Robin Woolfson and his co-authors wrote in Saturday's issue of The Lancet.
An active ingredient in Longdan Xieganwan is aristolochic acid, which is recognized as a potent carcinogen.
The man developed a bladder tumour that was surgically removed.
He stopped taking the herb, but when doctors last saw him in June 2006, he had developed recurrent bladder tumours and kidney failure requiring dialysis.
Tonic still available
"Aristolochic acid has been banned in many countries but continues to be available on the internet," the researchers said.
"This case emphasizes the importance of an adequate environmental and dietary history in [urinary/kidney] disease and highlights the dangers of unregulated herbal therapy."
Since 1993, when more than 100 people at a Belgian diet clinic suffered kidney damage after being exposed to aristolochic acid, regulators in the United States, Canada, Britain, Malaysia and other countries have banned aristolochic acid or issued strict warnings about it.
In 2005, Health Canada repeated its warning not to use products containing aristolochic acid.
Aristolochic acid is not authorized for sale in Canada, but travellers returning to the country can bring it in for personal use, the advisory said.
Longdan Xieganwan is manufactured by China Tong Ren Tang, China's oldest supplier of traditional medicine.
Recently, more than 100 Chinese kidney patients started a class-action lawsuit against the company in the country's first consumer action, the British team said, citing a Chinese newspaper report.
A journal editorial accompanying the case report said complementary medicines, like any medicines, have the potential for side-effects, drug interactions and contamination and need to be regulated.

Thursday, July 20, 2006

Alternative health treatments gain more adherents

http://www.chicagotribune.com/entertainment/chi-0607190034jul19,1,5161136.story?track=rss&ctrack=1&cset=true

By K. Oanh Ha
San Jose Mercury NewsPublished July 19, 2006
After three years of trying to conceive and three failed attempts at in-vitro fertilization, Tracey Carroll, 33, desperately turned to the East for help. She sought the needles and herbs of an acupuncturist.In fact, her new in-vitro doctor insisted. After she had her fourth session of getting pricked, her menstrual cycle became regular for the first time in three years. Carroll also swallowed 18 pills of "smelly, yucky herbs" of which the ingredients were derived from cow spleen and pituitary gland believed to regulate her hormones.Six months later, the woman is now expecting twins, due in December -- and believes acupuncture played a large role.Carroll is among an increasing number of American women who are turning to alternative, Eastern medicinal arts for such issues as infertility, menopause and dry skin.Once seen as quackeryOnce dismissed as mystical quackery by many medical doctors, acupuncture treatments are now recommended by some in-vitro specialists as a way to increase fertility. Meanwhile, other women turn to ayurveda -- a 5,000-year-old practice from India that incorporates mind, body and spirit -- to ensure health. Women turn to it to rid their body of toxins and dull skin. Both Eastern holistic approaches employ herbs and massage or acupuncture.Immune system diagnosisCarroll, a teacher, says that in her first session, Milpitas, Calif., acupuncturist Robin Hays diagnosed that her natural killer cells in her immune system were elevated, which meant her body might attack an embryo. Later, blood tests confirmed it.Acupuncture, an integral part of traditional Chinese medicine, stimulates blood flow and encourages better circulation. Needles are inserted into the body at various energy points, which correspond to organs in the body. Acupuncturists also employ herbs to bring balance to the body.For women trying to conceive, acupuncture often focuses on the uterus, Hays says."It's creating a fertile valley to grow a seed or an embryo," she says. Hays, who turned to acupuncture for a sprained ankle two decades ago, was so delighted with the results that she pursued it as a profession. She graduated from San Francisco's American College of Traditional Chinese Medicine in 1985.Back then, it was mostly Chinese and older hippies who turned to acupuncture, Hays says. Her patients didn't even tell their primary doctors about it because most of the medical establishment eyed it suspiciously. Now, some insurance plans cover acupuncture, and she's getting referrals from doctors, including Dr. Christo Zouves of the Zouves Fertility Center in Daly City, Calif.Eighty-five percent of patients at the fertility center undergo acupuncture as part of their treatments, Zouves says. He also recommends yoga, meditation and eating healthily."It's about the mind/body connection," says Zouves, who adopted Eastern holistic approaches to his practice a decade ago.Mysterious methodHis experience and medical studies show that acupuncture stimulates blood flow to the pelvis and uterus. "We don't know how it works, but it does," he says.At Hays' practice, about half of the patients see her for women's health issues, including premenstrual syndrome, irregular menstrual cycles and menopause. She also treats many patients for pain disorders and allergies."Most of my patients come because they don't want to take drugs," she says.Meanwhile, other women are turning to ayurvedic remedies, which use herbal treatments, tailored diets and massage to build up immune systems and detoxify bodies. Across the country, ayurvedic spas have sprung up to pamper women and promise radiant skin. A survey of spas offering "wellness treatments" in 2004 found that 12 percent added ayurvedic services while an additional 7 percent planned to, according to the International Spa Association.Ayoma LifeSpa in San Jose, Calif., offers ayurvedic massage treatments as well as longer-term nutritional consultations for regular members. Before each treatment, clients fill out a questionnaire so an ayurvedic consultant can gauge the imbalances in their body."All ailments in your body have to do with something you're eating," says Jenny Rodriguez, the spa's owner.According to ayurvedic philosophy, a person's health is governed by three biological forces -- vata, pitta and kapha -- that need to be in balance. Illness and disease stem from imbalances, and treatment seeks to equalize them. Too much vata, for example, causes dry, sensitive skin.Ayoma's treatments emphasize skin and the release of toxins through massage. Herbal oils and exfoliants made from chickpeas and lentils are used. The "shiro abhyanga" head massage, for example, releases toxins, according to the menu. Another favorite is the third eye treatment, where warm herbal oil is continuously poured for 40 minutes onto the center of the forehead, which adherents believe contains energy.Marsha Fischer of San Jose is a new convert. The high-tech sales representative discovered the spa earlier this year and goes in every few weeks to "de-stress and relax," she says. On a recent appointment before her period started, she says she felt bloated and uncomfortable. The warm oil massage focused on her stomach, a first for her. "It felt weird," she recalled. "But it worked."

New Business in New York

Apothecary offers alternative health care

http://www.poughkeepsiejournal.com/apps/pbcs.dll/article?AID=/20060719/BUSINESS/607190328

Dr. Tom's Tonics — A Modern Apothecary, 6384 Mill St., Rhinebeck, will hold its grand opening at 6:30 p.m. Friday.
The shop, run by Dr. Tom Francescott, a naturopath, features natural herbs, vitamins, salves and soaps as well as crystals and other items.
Francescott said ever since he graduated from medical school at Bastyr University in Seattle, he has wanted to open a retail store. But, he started his practice first three years ago — in another office in the same building.
"When this space first became available a year ago, that's what prompted me to open the shop," he said.
He said there is always a doctor in the shop.
"The old concept of an apothecary is it was a pharmacy that dispensed remedies, and had a lot of knowledge and experience. We have someone dispensing advice and our products are pretty innovative," he said. Many are product lines sold only to doctors.
"My medical experience is the difference," he said. For example, he said, earlier in the month he refused to sell a particular vitamin to a customer because he believed, based on what he was told by the customer, it wasn't needed.
The shop opened May 5 and has three employees. It is open 10 a.m. to 4 p.m. Tuesdays and Thursdays, and 10 a.m. to 5 p.m. Fridays through Mondays.
During the grand opening, there will be free healthy food and beverages, door prizes, music and more.
For information, call 845-876-2900.

Monday, July 17, 2006

Thieves stripping elm bark for herbal remedy

http://news.cincypost.com/apps/pbcs.dll/article?AID=/20060717/NEWS02/607170361

By Samira JafariAssociated Press
DANIEL BOONE NATIONAL FOREST - The 20-foot tree stands half naked surrounded by the lush green of the forest. Stripped of its lifeline to nutrients and water, it only has months to live.
"It doesn't know it's dead," says David Taylor, a U.S. Forest Service botanist for the Daniel Boone National Forest, pointing overhead to the healthy leaves that pose a stark contrast to the rest of the tree's withering body.
This slippery elm has fallen victim to thieves who tore off its bark for profit in the ever-popular herbal remedy market.
The gummy lining of the tree's bark has long been used in North America, and especially Appalachia, as a soothing agent for coughs, gastrointestinal ailments and skin irritations. However, experts say a growing interest in herbal products is exhausting many native plants like slippery elm - once used seasonally by locals, now in demand by millions.
"I think that trend is going to put pressure on limited resources such as the slippery elm," said Dr. Michael Hirt, founding director for the Center for Integrative Medicine in Tarzana, Calif.
Added John Garrison, a National Park Service spokesman for the Blue Ridge Parkway: "There's a huge market in botanicals going into herbal medicines. Virtually everything on public lands has a market."
Dietary supplements, which include the subcategory of herbal supplements and remedies, are a $23 billion industry, according to the National Institutes of Health.
Some 62 percent of Americans use some form of complementary or alternative medicine, which includes a variety of therapies, from acupuncture and meditation to herbal remedies and folk medicine. About 20 percent use some form of natural products.
The herbal industry credits natural remedies and supplements as a cheaper, and usually safer, alternative to pharmaceuticals - especially for mild ailments.
"A lot of people have become disillusioned with the safety of pharmaceuticals and the associated high cost," said Mark Blumenthal, founder and executive director of the American Botanical Council.
Blumenthal and Hirt cited drugs such as Vioxx, an arthritis medication linked to dangerous side effects and pulled from the market in 2004, as examples of pharmaceuticals that have turned off many Americans to synthetic prescriptions.
Even so, herbals also have their share of problems. For example, ephedra, a natural stimulant often sold as pills or tablets usually taken for weight loss and more energy, was banned by the federal Food and Drug Administration after being linked to deaths.
But the interest in herbal products remains strong, fueling many to poach plants in the wild to turn a profit.
In the past, forest and park officials have had to battle thieves snatching a variety of botanicals, most commonly American ginseng - thought to fight fatigue and stress-related ailments.
Great Smoky Mountains National Park officials recently teamed up with the North Carolina Department of Agriculture to mark ginseng roots with a permanent dye and transponder strips to track illegally picked ginseng.
In the case of the slippery elm, officials at the U.S. Forest Service are relying on locals to alert them to illegal stripping.
Slippery elms are native to North America and can be found from Canada to Texas, generally growing around cool, wet areas, like creek beds. Authorities say the prime season for stealing is mid-June and early July, when the bark is mucilaginous and easy to peel.
Since the wood of the slippery elm has no commercial value, the stripped trees are left to die. About a dozen trees face that fate for each 50-pound of sack of bark, which fetches about $35 if the bark is wet, $150 if it's dry.
"You've got some old mountain boys who know the trees, know the terrain," said Officer Barry Bishop, with the federal Forest Service, about the half dozen suspects the Daniel Boone Forest has arrested this summer.
"If you find enough trees, it's not going to take long to get a few pounds," added Taylor. "It's a quick buck."
The demand for the bark has landed the tree on a protection list by the Ohio-based National Center for the Preservation of Medicinal Herbs, a nonprofit which researches safe ways to grow and replenish medicinal botanicals, such as ginseng, blood root and black cohosh.
While the Forest Service issues permits for the harvesting of some plants, such as ginseng, it does not permit any type of bark removal because it cripples trees. "It's not a life-saving herb that's worth destroying forests over," Hirt said.
Armando Gonzalez-Stuart, a researcher at the University of Texas El Paso/Austin Cooperative Pharmacy Program, said the best option is for herbal industry to cultivate the trees responsibly on private property. If the bark is harvested in a sustainable manner, the trees are more likely to survive for future harvesting.

Scientists Isolate Leukemia Stem Cells In A Model Of Human Leukemia

http://www.sciencedaily.com/releases/2006/07/060717102410.htm

Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston and their colleagues have isolated rare cancer stem cells that cause leukemia in a mouse model of the human disease. The leukemia stem cells isolated proved to be surprisingly different from normal blood stem cells -- a finding that may be good news for developing a drug that selectively targets them.

Cancer stem cells are self-renewing cells that are likely responsible for maintaining or spreading a cancer, and may be the most relevant targets for cancer therapy. The discovery provides answers to the longstanding questions of whether cancer stem cells must be similar to normal stem cells, and what type of cell first becomes abnormal in leukemia, the most common form of cancer in childhood. The journal Nature has posted the study's findings online in advance of print publication.
It had been speculated that leukemia begins in a totally undifferentiated stem cell that can become any type of specialized blood cell and has the ability to renew itself almost without limit.
Instead, the scientists showed that they could create leukemia stem cells, which also are self-renewing, from partially committed, non-self-renewing progenitor cells. The latter are short-lived cells that can turn into several types of blood cells, but are more committed than stem cells, which can become any kind of blood cell and also are virtually immortal.
"Our data supports the idea that leukemia stem cells do not have to originate from normal blood stem cells. Furthermore, we have shown that fully developed leukemia stem cells do not necessarily have the same genetic program as normal stem cells," said Scott Armstrong, MD, PhD, of Dana-Farber and Children's Hospital and senior author of the paper. "This is an important finding, because it indicates that in the future we should be able to specifically target leukemia stem cells without killing normal stem cells."
Leukemias are cancers of the blood-forming tissues of the bone marrow in which white blood cells proliferate abnormally, with life-threatening effects. About 35,000 diagnoses of all types of leukemia will be made in 2006, according to the American Cancer Society, with about 22,280 deaths. Some forms of leukemia have a high rate of cure. In other forms, chemotherapy may initially put the patient's disease into remission, but after months or years the cancer reappears and may be fatal.
Many scientists believe that relapses are caused by the survival of a handful of leukemia stem cells mixed in with the population of cancer cells. These cells have gained self-renewal capabilities, and, if not killed by chemotherapy, can lie dormant in the bone marrow and eventually trigger new growth of the leukemia. Current thinking is that cure rates of leukemia and other cancers could be improved if the cancer stem cells could be identified and selectively targeted with designer drugs.
To test this hypothesis, the researchers sought to transform a normal, partially committed progenitor blood cell from a mouse into a leukemia stem cell, and then determine whether that stem cell was more like a normal blood stem cell or instead resembled the progenitor. As a first step, they inserted an abnormal gene, MLL-AF9, which causes a type of acute myelogenous leukemia (AML) in humans, into partially committed mouse blood cells known as granulocyte macrophage progenitors, or GMPs. These genetically altered cells were injected into mice, which subsequently developed AML.
Through several steps of purification, the researchers winnowed down the leukemia cells from the mice to a small population that contained a large percentage of leukemia stem cells -- as evidenced by the fact that they could induce cancer in normal mice using successively smaller amounts of cells, since only the stem cells cause the disease when injected. "Such a pure population of leukemia stem cells had not been isolated before," said Andrei Krivstov, PhD, of Children's Hospital Boston, the paper's lead author. "We are the first to transplant as few as four cells and induce leukemia in the mice."
The investigators next compared gene activity in the leukemia stem cells with that in the original partially committed progenitor cells, and in normal uncommitted blood stem cells. Using microarray technology, they compared the cells' gene expression patterns -- that is, which genes were turned on and which were turned off.
In terms of gene activity, "the leukemia stem cell looks most like the committed progenitor," said Armstrong, who is also an assistant professor of pediatrics at Harvard Medical School. "But there's a program of a few hundred genes that are turned on in the progenitor, which appears to give it the ability to self-renew. It's almost as if the abnormal gene we inserted knows what to do to turn on the program that makes it a self-renewing cancer stem cell."
The scientists referred to the gene activity pattern they discovered as a "signature" of self-renewal. Their next efforts will be to determine which genes among the several hundred that were particularly active or inactive are the most responsible for the cancer cell's behavior. These genes might eventually become targets for new types of drugs.
Moreover, said Armstrong, knowing the gene signature of an individual patient's leukemia might be useful in predicting how difficult it will be treat it and for evaluating the success of treatment. So far, researchers have not identified and isolated a pure population of leukemia stem cells in humans with the disease. The gene expression signature might be used to identify leukemia stem cells in the human disease, and the presence of a large number of leukemia stem cells could indicate a poor prognosis.
The paper's other authors are affiliated with Dana-Farber, Children's Hospital Boston, Brigham and Women's Hospital, the Broad Institute of Harvard and MIT, and the Howard Hughes Medical Institute.
The research was funded in part by the National Institutes of Health, the Leukemia Lymphoma Society, the Richard and Susan Smith Foundation, and the Damon Runyon Cancer Research Foundation.

What Chinese medicine can teach Vt.

http://www.burlingtonfreepress.com/apps/pbcs.dll/article?AID=/20060717/OPINION/607170317

July 17, 2006Anne T. O'Brien The cost of health care and access to it is a huge concern for many Americans. As both a consumer and practitioner of medicine in Vermont, it is clear to me that people are both benefiting from and suffering under the current system. Health care is costly and while Vermont's health care professionals are working hard to heal, help and cure diseases, it has become apparent that western medicine on its own is not always successful at making us responsible for our own health -- or empowering us with the resources to do so. In researching the healing practices of other regions, I have found many interesting practices used around the world where cultures without access to all of modern medicine's treatment options achieve and maintain healthy lifestyles through other means. One such method is a cornerstone of traditional Chinese medicine called qigong. This ancient discipline has been used in China for millennia and today, over 60 million Chinese practice these techniques to maintain and promote health. Qi (pronounced "chee") is breath or energy, and gong (pronounced "gung") is the skillful working of the qi. In harmony and under the right tutelage (Qigong Masters), these two forces can help emit healing energy from the body. The benefits of qigong have been shown to reduce healing time after surgery by half, normalize the blood pressure, heal tuberculosis and liver disease, relieve myopia, improve mental performance, reduce the frequency of strokes and deaths related to high blood pressure, and improve blood sugar levels in diabetics. Qigong also has been effective in the treatment of substance abuse, obesity, respiratory conditions, asthma, the effects of aging and allergies. In largely rural areas like Vermont, this practice might seem as inaccessible as China itself but this summer, the University of Vermont is bringing the healing powers of the east to the Green Mountains. Under the instruction of Dr. Effie Poy Yew Chow, a world renowned energy medicine practitioner who has been practicing medical qigong for over 40 years will be a guest faculty at UVM teaching a course in Healing Qigong this month. She will be conducting an intensive QiGong weekend class beginning the evening of July 21 and concluding on Sunday July 23 as part of UVM's Healing Therapies 2006 program. Chow is an award-winning healer and teacher. She is the president of the East West Academy of the Healing Arts and a former Chair of the World Congress on Qigong. She was appointed to the White House Commission on Complementary and Alternative Medicine Policy by President Clinton. If nothing else, our current health care system serves to motivate everyone to become accountable for his or her own well-being. If you are a health care practitioner or person with an illness, or are simply interested in improving your own qi, please take advantage of this course and the expertise of its very special and highly talented teacher. This introduction to qigong will be informative, culturally interesting and may open a door to a low-cost, yet powerful, tool for optimizing the health care of all Vermonters. Given the history and current use of qigong by tens of millions of people worldwide, this practice is certainly sustainable and worth a second look as we examine our options for achieving physical and mental balance, maintaining good health and, most importantly, reversing the downward spiral of chronically ill Vermonters.The writer is senior curriculum developer and chairwoman of the health care team at the University of Vermont's Department of Continuing Education. For more information, visit learn.uvm.edu/healingtherapies.

Saturday, July 15, 2006

Love that bottled water

http://www.athensreview.com/health/cnhinshealth_story_194234746.html?keyword=topstory

By Rosemary Ford and Julie KirkwoodTHE EAGLE-TRIBUNE (NORTH ANDOVER, Mass.)
NORTH ANDOVER, Mass.— Water is water, unless it’s water.Artesian, spring, distilled, flavored, enhanced: Water of all varieties can easily fill supermarket aisles, with dozens from which to choose.It may be the most plentiful substance on Earth, but lately bottled water is the most lucrative substance in the beverage industry, with worldwide sales exceeding $20 billion. Almost unthinkable 20 years ago, bottled water has become a staple of our culture. On local playgrounds, it’s more usual for a child to sip from a Poland Spring bottle (especially one shaped like a bubble) than the Bubbler — if there is one. “I absolutely believe (today’s children) are the bottled-water generation,” said Chris Testa, founder and chief executive officer of Wild Waters, which just launched a flavored water line aimed at kids, fortified with vitamins and nutrients. “But kids don’t want to leave their juice drinks for something that lacks taste,” Testa added. “Plain water is plain,” Testa said by way of explanation for why flavored and enhanced waters are finding an audience with adults as well as children.There are some people who don’t care about the brand. Whatever is on sale usually ends up in the shopping cart.“I find that (brand) loyalty is quickly fading away,” said water expert Jason Borane from Aquabar, which distributes and markets nonalcoholic beverages. “As more and more boutique brands are hitting the market, people are beginning to question that loyalty. It’s not the day when people can just choose still or sparkling.” But for those who notice and care about such things, retailers are trying to differentiate themselves, whether it’s to tout the exotic and uncontaminated locales from which their water originates, the enhancements that boost water’s naturally neutral flavor, or the added vitamins and minerals said to boost athletic performance.Some waters come from deep in the ocean, desalinated for drinking. Others, like Fiji, come from deep in a rocky aquifer or well, untouched by air until that first twist of the cap. “We make a great effort to communicate with customers that they are getting natural water from Fiji,” said Grace Leon, vice president for marketing.When it comes to these “luxury,” or premium, waters, part of the romance is in the bottle, whether its the tropical rectangle of Fiji, the mountain top of Icelandic Glacier, or the bubble of Ogo. “Thoughts of Iceland immediately conjure up images of purity, glacial lagoons, mountains, ice and a pollution-free environment,” said 20-year water industry veteran Patrick Racz, chief operating officer of Icelandic Water Holdings, makers of Icelandic Glacial. “One glance at our product immediately tells you that it is exceptionally pure water from Iceland,” he said. When it comes to sports, any type of hydrating fluid is going to make you perform better and feel better, said Douglas Casa, a hydration expert at the University of Connecticut who holds a doctorate in exercise physiology.Many waters are enhanced with electrolytes or oxygen, which is touted as a stimulant for the brain, or a way to enhance blood flow.Casa disputes the effect of such additions. “There’s no evidence that bottled water is any better than just tap water,” he said.There’s also an emerging market for flavor packets, which can be a cost-effective way to flavor your water. “I know I need to drink eight to 10 glasses a day, but it’s just blah,” said Nina Riley, head of Water Sensations, which sells six flavors that can be added to water. She developed the packets out of her own search for a cost effective way to jazz up the water she and her family drank. “People do want to drink more water, it just gets boring,” she said. Some diehards, however, continue to believe water remains just water.“There isn’t that much you can do to water, at the end of the day,” said Leon.Rosemary Ford and Julie Kirkwood writes for The Eagle-Tribune in North Andover, Mass.

Older adults with low testosterone prone to anemia

http://news.yahoo.com/s/nm/20060714/hl_nm/testosterone_anemia_dc_1

By Megan RauscherFri Jul 14, 1:55 PM ET
Men and women older than 65 years of age with low testosterone levels are at increased risk of being or becoming anemic, researchers report.
While testosterone is considered the 'male' hormone, women normally have some -- albeit at lower levels than men.
"Low testosterone levels could be a susceptibility factor for anemia that has been generally neglected," Dr. Luigi Ferrucci, from the National Institute on Aging in Baltimore, Maryland, and colleagues suggest in the Archives of Internal Medicine.
"Low testosterone levels," they write, "should be considered a potential cause or co-cause of anemia in older men and women, especially when other plausible causes have been excluded, and in patients with nutritional deficiencies in whom nutritional supplementation of iron and vitamins has been ineffective."
The team's findings are based on an Italian population-based study, in which testosterone and hemoglobin levels were measured in a representative sample of 905 older adults, 65 years of age or older.
Hemoglobin is the oxygen-carrying component of red blood cells. Anemia was defined as a concentration of hemoglobin below 12 grams per deciliter of blood for women and below13 grams per deciliter for men.
At the start of the study, 31 men and 57 women had anemia, based on their hemoglobin measurement.
Men with the lowest levels of testosterone were five times more likely to be anemic than men with the highest levels, the researchers report. For women, low testosterone doubled the likelihood of anemia.
Among those without anemia at baseline, men and women with low versus normal testosterone had a significantly higher risk of developing anemia within three years.
Despite the statistically significant association between low testosterone level and low hemoglobin level, many subjects with low testosterone were not anemic and many of those who were anemic had testosterone levels in the normal range.
"These findings," write the authors, "suggest that a low testosterone level increases susceptibility to anemia but may not be a sufficient causal factor for anemia, probably because the effect can be counteracted by alternative mechanisms."
Summing up, Ferrucci and colleagues conclude that anemia in older adults is likely to be the result of multiple factors. Understanding the causes of anemia in this population is important "because anemia in older persons is frequently unexplained and is associated with a high risk of disability and accelerated decline in physical function," they point out.
SOURCE: Archives of Internal Medicine, July 10, 2006.

Five-Finger Solution: Alternative Doc Says Its All In The Hand

http://www.queenstribune.com/feature/Five-FingerSolutionAlterna.html

By CHARLES ERICKSON
Jong Seo Lim, a chain-smoking acupuncturist and herbal-medicine man in Woodside, speaks in a whisper.As Dr. Lim explained recently, with hushed tones and hand gestures and wearing blue surgical scrubs, he lost his voice in 2001 – after he poured cold water over his head while in a bathtub.That was the year before he opened Samson Herb and the Ko Ryo Sooji Therapy Center, his dual businesses at 56-16 Woodside Ave. The little storefront serves as an acupuncture treatment center, pharmaceutical plant and possibly as his living quarters. Years Of ExperienceLim, who said he came to the United States from Korea in 1977, isn’t very good with time. He pulled his checkbook from the drawer of a desk in the front room and tried to use its entries to fix the establishment’s opening date. He finally turned around and consulted one of the framed certificates hung on a wall. It put the opening as having occurred in April 2002.Other papers displayed in the front of his office proclaim him a master of Oriental medicine, a diplomat in acupuncture, a 1973 graduate of the Koryo-Sooji-Chim Research Institute. Another certificate, dated 1980, is all in Korean and shows a photo of the proprietor, looking much younger, as he appeared 26 years ago.Before his vocal problems, Dr. Lim probably spoke in heavily accented English. However, he understands the Anglo tongue well and conveyed information to a questioner by nodding to affirm that certain statements and details repeated back to him were correct.The only employee here, Lim practices mainly hand acupuncture but learned both this and the full-body style in Korea.Herbal SolutionsIf his probing fails to restore their health, the doctor makes his patients herbal remedies.Held on shelves throughout the store are the various herbs that are used in the manufacture of more than 500 different natural medicines. They come in large plastic bags that make crackling sounds whenever they are handled.A recent herbal inventory included paeoniae radix, forsythiae fructus, mori folium, angelicae gigantis radix, achyranthis radix and radix ginseng. Many of the bags carried the markings of a Woodside importing company.Lim opened the freezer portion of a white refrigerator that is kept in front. It would not look out of place in a modern kitchen.He removed two wedge-shaped objects, both frozen inside clear plastic. Except for their coloring – one was mostly brown, the other was mostly black – they resembled a summertime treat of the kind sold at corner markets.“I made it. I packed it,” he said of the medicines, kept frozen to preserve their healing abilities.

Samson Herb and the Ko Ryo Sooji Therapy Center operate along a mostly residential section of Woodside Ave. PHOTOS BY CHARLES ERICKSON
The Magical Mystery TourLeading an impromptu tour of the facility, Lim showed off some secrets of where and how he practices his medicine. Two curtained acupuncture rooms, one for women and one for men, are in the small hallway that separates the front and rear of the store.An Asian woman, looking weak and pale and being fed a yellowish herbal remedy by a female relative, was slumped in the women’s chamber. The smell was like that of steamed bamboo and stale tobacco smoke.Seeing a camera, her husband, a smiling man in a white dress shirt, offered her as the subject of a photograph. But this seemed like a further indignity for the suffering woman.Lim began making herbal medicines atop a wooden desk. Illumination is from a lamp with no shade. He measures quantities with a post office scale, and chops or mulches herbs with a pair of kitchen blenders. One is an old Osterizer, the other is newer and has Korean script on its control pad.The mash is then placed in cotton bags and walked to a complicated device positioned against the far wall. It is constructed mostly of stainless steel, and the wheel crank used to tighten shut one of the cylinders gives the cooker the appearance of a fixture on a naval warship.Also in back are a small bathroom and, unseen, perhaps a place where the medicine man sleeps. Lim’s comprehension of English seemed to wane when asked about where he makes his home.He slowly walked out to the front of the store. The Key To Everything“Hand is important,” Lim said as a visitor joined him again in the lobby. He was standing next to a wall poster that showed a skinless human in side profile from the head to the hips.The Latin alphabet was absent from the chart, but the imagery was clear. Various organs were shown in expanded size – eyes, heart, lungs, intestines, bladder and others – and lines were drawn from them to the illustrated front and backsides of a hand.And then, using his right hand, the same hand he uses to hold his Marlboro Ultra Light 100s, Lim tapped the poster and repeated, “Hand is important.”

Malaria risk for tourists who trust alternative practitioners

http://www.timesonline.co.uk/article/0,,8122-2269389,00.html

By Mark Henderson, Science Editor
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Alternative health centres are giving backpackers dangerous advice on malaria prevention by recommending unproven homoeopathic remedies instead of effective conventional drugs.
An investigation has revealed that every one of ten randomly selected homoeopathic clinics and pharmacies was willing to recommend its products as an alternative to proven prophylactic drugs, in defiance of advice from the Health Protection Agency.
The findings prompted leading tropical medicine experts to warn travellers that homoeopathic preparations offer no protection against malaria and other life-threatening diseases, and should never be taken instead of preventive treatments that do work.
Homoeopathy is controversial as there is no scientific evidence that it is effective. Remedies are created by diluting substances to an extreme degree, usually so not a single molecule of the main ingredient is left, and most scientists consider that its only medical value lies in the placebo effect. It is generally accepted that the remedies are not themselves dangerous, as they contain no chemically active ingredients, but they can put people at grave risk when used in place of medications that are needed to treat or prevent disease.
Ron Behrens, director of the Hospital for Tropical Diseases Travel Clinic in London, said that it is critical that people visiting malarial regions do not substitute homoeopathic preparations for prophylactic drugs.
“We are urging the public to take on board this warning at a time of year when many people are planning to travel,” he said. “The misleading travel advice being given by homoeopaths is not a trivial problem. We have treated people at the Hospital for Tropical Diseases who thought that they were protected by homoeopathic medicines and contracted malaria. The messages given by some homoeopaths are inaccurate, counter-productive and place lives at risk.”
Professor Brian Greenwood, of the London School of Hygiene and Tropical Medicine, said: “The use of homoeopathy creates a more dangerous situation than taking no precautions if the traveller assumes that she or he is protected and does not seek help quickly for any illness that might be malaria.”
In the investigation, Simon Singh, a science writer and broadcaster, picked ten clinics and pharmacies at random from the internet, and sent Alice Tuff, an intern with the charity Sense About Science, to approach them for advice.
Ms Tuff, 23, posed as a backpacker about to start a ten-week truck tour through central and southern Africa that would take her through several malarial zones. She told each homoeopath that the anti-malarial drugs prescribed by her doctor were making her feel unwell, and asked whether they could provide an alternative.
In every case, a homoeopathic remedy was recommended, and none of the practitioners advised Ms Tuff to keep taking her conventional drugs. None referred her back to her GP, who would have been able to prescribe an alternative drug that might have more tolerable side-effects.
Only three of the homoeopaths advised on mosquito bite prevention, and only one gave advice on the symptoms of malaria and recommended that she seek professional medical help if she experienced these. Four of the homoeopaths offered anecdotal stories of patients who had used their preparations to prevent malaria.
Dr Singh said: “Homoeopathy is not just useless, it is worse than useless in the case of malaria because it dupes people into thinking that they are protected when they are not. I was shocked that there was such willingness to give advice and sell products that would leave people exposed to a highly dangerous disease.”
Melanie Oxley, of the Society of Homoeopaths, said that she was concerned by the findings, as there was no evidence that homoeopathy could guard against malaria. It should be used together with conventional medicine, she said.
BITE THAT KILLS THREE MILLION A YEAR
THE most severe form of malaria is caused by the Plasmodium falciparum parasite, which is transmitted by the bite of the female Anopheles mosquito
It kills more people than any infection other than HIV/Aids, with an annual death toll estimated at between 1 million and 2.7million. It infects between 300 million and 500 million people a year, mainly in Africa
The Health Protection Agency advises visitors to regions where malaria is endemic to take prophylactic drugs. The options are a combination of chloroquine and proguanil, mefloquine (Lariam), doxycycline and Malarone. These can have unpleasant side-effects, but most people can, through trial and error, find one that is tolerable
Last year 1,754 Britons contracted malaria abroad; 1,300 contracted the deadliest strain, P. falciparum. Eleven of them died. Most had not taken prophylactic tablets or had failed to take them as advised
Homoeopathic remedies are diluted many times; often none of the original drug remains in the preparation. Homoeopathy is based on the notion that ailments will be cured by taking small quantities of substances that provoke similar symptoms
There is no evidence that any homoeopathic preparation is effective against malaria
Three homoeopathic preparations were recommended for malaria prevention: malaria officinalis, made from tissue from a sick person or vegetation from malarial swamps; China sulph, made from quinine-producing trees; and natrum mur, based on salt

Hashing over herbs

http://www.standard.net/standard/84194

Tuesday, July 11, 2006
By Becky WrightStandard-Examiner staffbwright@standard.net
Book promotes the value of herbal medicine
Need to lower your cholesterol? Try treating it with prickly pear. Suffering from severe migraine pain? Use periwinkle vine. Prone to kidney stones? Pick and prepare some of the mallow around your yard.
Local plants have many medicinal uses, according to Charles W. Kane -- so many that he wrote a book, "Herbal Medicine of the American Southwest: A Guide to the Identification, Collection, Preparation, and Use of Medicinal and Edible Plants of the Southwestern United States" (Lincoln Town Press, $29.95).
"I've been helping people with chronic issues, stress problems and lifestyle problems for a while," said Kane, who is a lay practitioner with the Tucson Clinic of Botanical Medicine.
In his book, Kane discusses more than 250 plants, offering step-by-step instructions for making everything from teas and salves to poultices and cough syrups.
Stephen L. Clark, a botany professor at Weber State University, says the ideas presented in Kane's book may seem strange and new to some people, but herbal medicine has been around for a long time.
"In fact, this is the oldest of medicines. Our Western medicine is the new stuff," he said. "The chimpanzees use medicinal plants, so it actually predates human history."
More important, Clark said, it works -- sometimes better than modern treatments.
"Probably 80 percent of the people in the world use plants for medicine. Not in the sense that we go to a pharmacist. They just go into the savannah or the woodlands or the rain forest, and they collect plants," he said. "If you get sick, you go see the local healer and they treat you with the plant or plant concoctions."
And it's from those healers -- shamans and medicine men -- that scientists get ideas for new drugs.
"It wasn't that Pfizer or Merck put a bunch of research scientists together in a laboratory somewhere and concocted this stuff," said Clark. "The thing you have to understand is that almost all of the knowledge we have in modern medicine came from a traditional healer. You go down and become one of those people and gain their knowledge through trust."
The difference
Clark says there is a fundamental difference between herbal preparations and pharmaceutical preparations. Pharmaceutical companies try to find a single chemical compound that is the active ingredient and isolate it.
"Then they give you a massive dose of a single compound and, granted, they are very effective. You can't say too much bad about the history of Western medicine -- it's good, it works -- but oftentimes you have very, very powerful side effects, too."
Herbal medicines are based on multiple plant compounds.
"It takes longer amounts of time to see the effects," Clark said. "And barring any kind of allergies or reactions, typically you don't have horrible side effects."
Clark and Kane recommend a balanced approach.
"I think what people should do is use the best of Western medicine and the best of traditional medicines -- use what works," Clark said. "If you have a severe infection of any kind and you need an antibiotic, there is no substitute in an herbal for a powerful antibiotic, there really isn't. ... If you have major trauma, or you have a heart attack, you go see a doctor."
Do careful research
If you want to make and use herbal medicines, Clark says, do your homework.
"I'm firmly convinced that lots of plants, and I use many of them, have absolutely incredibly valuable medicinal uses -- but I have checked the research on every one of them. And you have to do that."
That means not only reading several how-to books, but also finding the results of research conducted on plants.
According to Clark, the American Botanical Council is a good source, producing books and a Web site, www.herbalgram.org. Web searches can turn up additional credible sources.
The bibliography of Kane's book includes references such as the Journal of Ethnopharmacology and the journal Phytochemistry.
Beware interactions
Research not only confirms or refutes claims about plants, but also contains important information about possible drug interactions.
For example, Clark says, it's not a good idea to treat a heart condition with garlic if you're taking a prescription medication such as Plavix.
"The garlic interferes with the treatment of the Plavix, so there are drug interactions that take place," he said. "Anyone who is on any kind of prescribed medication from your doctor has to be very cautious not to just shotgun approach it, and say 'Well, let's do this other stuff, too,' because there can be very powerful, and sometimes very dangerous, interactions between a lot of these plants and whatever medication they're taking."
Deadly plants
Many people have the mistaken idea that because it's a plant, and it's organic, it's safe, said Clark.
But most plants are toxic. Local toxic plants include larkspur, monkshood, baneberry, locoweed, hemlock and most members of the carrot, buttercup and potato plant families.
"I can probably think of more plants up here that will kill you than I can think of plants you can use for medicine," Clark said.
That's why it's also important to check multiple sources and to take classes in plant identification and collection.
Some useful plants have deadly look-alikes.
"There are three plants that you might find within inches of each other: sego lily, blue camus and death camus," said Clark. "The bulbs look alike. ... You may think you're digging blue camus, but one-third of the bulbs in your pot may be death camus, which isn't cool."
Common plant names can also cause dangerous confusion.
"Years ago, I was watching TV and a guy was teaching an outdoor survival course," said Clark. "He talked about a plant that was edible called skunk cabbage. Well, skunk cabbage in Utah is an incredibly toxic plant (that) is a powerful chromosome mutagen -- I mean it resequences all your DNA. ... He was a really neat guy, and a very qualified guy in what he did, but he was not a botanist and he didn't know the plants. He had seen reference to a plant called skunk cabbage, which is edible, but it's a different plant (that) grows in Wyoming. ... So if you see a reference that says skunk cabbage is edible, you better know for sure which plant you're talking about."
Spread the word
A little bit of knowledge can be a dangerous thing, Clark stresses.
But an interest in plants as medicines, and an understanding of their importance, could be a great thing for their survival and ours.
"Humans in the Western world have lost contact with plants, and have become so silly as to think that we don't need them -- that we can denude the mountains and cover them with subdivisions and trams," he said.
"I'm surprised we haven't gotten rid of cows because milk comes in a carton. It's like thinking 'Who needs plants, when medicine comes in a little pill?' "
Clark says that kind of attitude will cause suffering in decades to come.
"We're losing botany, and we've got to make people aware of the fact that we still need plants."

Uproar in Peru over genetically-engineered diarrhea treatment

http://www.usatoday.com/tech/science/genetics/2006-07-14-diarrhea-treatment_x.htm?csp=34

Updated 7/14/2006 5:39 PM ET
By Rick Vecchio, Associated Press
LIMA, Peru — It should have been a triumphant moment for Dr. Nelly Zavaleta when many of the diarrhea-stricken babies she treated with an experimental U.S. drug got better quicker than expected.
Instead, one of Peru's top scientists finds herself a target of a criminal investigation, a professional ethics complaint and at the center of a global debate over food crops genetically engineered with human genes to produce drugs.
Zavaleta gave the babies an anti-diarrheal derived from rice genetically engineered to produce two key proteins in mother's milk. Last month, the Germany-based International Academy of Life Sciences, a biopharming advocate, hailed her research as a "revolutionary development."
Zavaleta's yearlong study at the Institute of Nutritional Investigation found that out of 140 babies hospitalized with serious diarrhea attacks, those given the proteins added to a standard rehydration solution recovered quicker — 3.67 days vs. 5.21 days.
The outcome is impressive, especially considering that diarrhea kills about 2 million children under age five every year. In Peru, it claims the lives of more than 7,000 children annually.
The experimental medicine Zavaleta administered is made by the U.S. biotechnology company Ventria Biosciences, which has amassed a large number of critics who complain it is recklessly developing a technology that threatens the safety of conventional food crops.
Many U.S. opponents, including conventional rice farmers, fear genetically engineered rice will inadvertently mix with their crops and cause them economic harm.
"It's not even just real contamination," said Rebecca Spector of the Center for Food Safety, which opposes biotechnology in agriculture. "It's also the threat of the contamination that could cause farmers to lose their markets."
Rice interests in California drove Ventria's experimental work out of the state in 2004, after Japanese customers said they wouldn't buy the rice if Ventria were allowed to set up shop.
To date, not one biopharmed drug has come close to market approval by the U.S. Food and Drug Administration.
That hasn't stopped U.S. biopharming companies from conducting clinical human trials of treatments grown in tobacco, corn and duckweed to fight everything from cancer and hepatitis C to cavities.
Ventria, a tiny Sacramento-based firm, has defied the intense opposition, plowing ahead in North Carolina with cultivation of genetically altered rice, spliced to produce the human mother's milk proteins.
Those proteins — lactoferrin and lysozyme — help people hydrate and lessen the severity and duration of diarrhea attacks, Peru's second biggest killer of children under 5 and a scourge throughout the developing world.
Zavaleta's troubles don't stem from the controversy over whether food crops should be used to make medicines. They are the result, instead, of accusations she endangered her young patients' health.
The accuser is Dr. Herberth Cuba. A gynecologist, Cuba runs the small but vocal non-profit Peruvian Medical Association, which claims without foundation to represent all Peru's licensed physicians.
Cuba complained to prosecutors that Zavaleta's experiments, in two public hospitals, were dangerous because they used "transgenetic products that haven't been approved in any nation, not even in the country of origin, the United States."
Peru was chosen for the study, he said, because it is a poor developing nation with lax enforcement of laws that Cuba insists strictly prohibit any medical experiments on children, with violations punishable by up to four years in prison.
Dr. Luis Bromley, chief of forensic investigations in Peru's attorney general's office, called Cuba's interpretation of the law wrong. Clinical trials involving children are permitted with informed parental consent and a lengthy approval process, he said.
Zavaleta maintains she adhered to all the requirements.
"All steps were followed with the ethics committees, with the approvals, with the parental consent," she said.
Dr. Justo Padilla, director of investigation at Peru's state-run Specialized Institute of Children's Health, which oversaw Zavaleta's research, said three independent scientific groups validated the research's safety before the trial began in August 2004. Among them were the Investigational Review Board at the University of California, Davis and a nine-member Peruvian ethics committee.
Nevertheless, Cuba's complaint must be fully investigated to ensure the clinical trial followed the rules to the letter, authorities say.
No matter that many in Peru's medical elite consider Cuba an irresponsible political gadfly who exaggerates facts to maximize publicity.
"He's becoming tiresome already in a situation that is alarmist and irresponsible," said Dr. Amador Vargas, dean of the Medical College of Peru, which has licensing and disciplinary oversight over the country's 46,000 physicians. The group's lawyer says Cuba faces several disciplinary charges and that his medical association has only about 200 members.
Asked for comment, Cuba replied: "They're all lies. That's all. Thank you."
Zavaleta's supporters lament how Cuba's complaint has hurt what they consider important, judicious research.
The treatment she administered could potentially put a huge dent in a chronic cycle of health problems associated with diarrhea, they believe, including malnutrition, infection, pneumonia and anemia, suffered by millions of children.
"It makes great political grist that foreigners are coming in and using genetically engineered materials on Peruvian children. That sounds pretty scary," said Dr. William Greenough III, a Johns Hopkins University professor and expert in pediatric and geriatric diarrhea.
"The fact of the matter is that we're taking purified, normal human breast milk proteins that have been exhaustively tested as to whether you could or could not even develop an allergy from them — which you can't," he said.
Greenough said the breast milk proteins can be produced in rice at a fraction of the cost of traditional laboratory methods, putting it "within reach of kids in very poor countries."
He has developed and commercially manufactures a normal rice-based oral rehydration treatment that he says lessens diarrhea's impact but does nothing to prevent it.
Greenough said he is using one of Ventria's breast milk proteins in a U.S. study to try to halt a common diarrhea that afflicts hospitalized elderly patients when they receive large doses of antibiotics.
"So we're not testing it in Peru because we can't test it in the United States," he said. "We're testing it in both arenas."
Neither Greenough nor Ventria would provide details on the study's sample or where it was taking place. Dr. Delia Bethell, Ventria's vice president of clinical development, said results would be published next year.
Ventria's chief executive, Scott Deeter, says the anti-diarrheal treatment that proved so promising in Peru is just the beginning.
He envisions putting Ventria's transgenic products within economic reach of poor countries around the world: "Plants are the most abundant source of affordable proteins on earth, which is why they are being developed as the ideal factory for affordable health products."

NMSU Fulbright scholar researches nutrition in Japan

http://www.demingheadlight.com/news/ci_4048542

By NMSU StaffDeming Headlight
LAS CRUCES — Her students are bewildered as Wanda Eastman, associate professor of human nutrition and food science, strolls into a crowded New Mexico State University auditorium, stands before them and bows.
Although it is not the custom for beginning class in the United States, Eastman acquired the habit while in Japan last year. "I do a lot of bowing, although I can't say the students are bowing back," she said.
Eastman just completed her first semester back at NMSU after spending four months as a Fulbright scholar teaching nutrition and conducting dietetic research at Siebold University in Nagasaki. A recipient of the Fulbright award for 2005, Eastman was one of only five U.S. educators to be selected to go to Japan.
Aside from daily bows, Eastman has come back to NMSU with knowledge and experience she plans to use in the classroom and for research. "I have found so many different things that I want to incorporate about nutrition from a perspective other than our own," she said.
Eastman was surprised at the differences between U.S. and Japanese eating habits. Throughout her 14 years at NMSU, addressing the nation's obesity problem has been one of her interests.
"A Japanese meal might be 12 courses but you would get 12 tiny things and you'd be full by the end," she said. "We don't have to have huge plates with food hanging off the edge to enjoy the taste of food."
Eastman said along with smaller portions, the meals were very healthy, consisting of fresh ingredients and very few sweets.
Although the food was quite different, Eastman said she felt very much at home with the Japanese dietitians, finding that the practice of nutrition is truly international.
Eastman was paired with Masatoshi Mune of Siebold University. Mune translated for the nutrition care management class and the graduate seminar in nutrition Eastman taught. In addition, he assisted her with the research part of her Fulbright award.
Eastman's research objective was to study Japan's dietetic practice and dietetic education. She spent much of her time examining the differences between diets recommended for people with diabetes in Japan compared with those in the U.S.
In the Japanese system, she said, diabetics choose from a list of six food categories, each serving consisting of 80 calories. The categories are starches (mostly rice), proteins (mostly fish), fats (mainly oils), fruits, dairy and vegetables. The U.S. diet is divided into only three food categories — carbohydrates, meats and fats — which are subdivided into major food variations.
Eastman found that Japanese diabetic meals do not place as much value on consistent carbohydrate intake as U.S. diabetic meals, but the Japanese diet in general is higher in carbohydrates and lower in fats and protein. Although she regards the U.S. system as more correct and consistent, she found that the Japanese method is easier to configure and teach to patients.
Renal (kidney) disease was another of Eastman's areas of research. Here the main difference between the diets of patients in the two countries was the amount of sodium. In Japan, sodium is consumed in higher amounts by patients as well as the general population. The Japanese renal dietitians she met considered U.S. recommendations too strict.
"Many Japanese foods are pickled. Soy sauce is used generously and foods are salted more at the table," Eastman said. Her one criticism of Japanese foods is the high use of salt.
As chair-elect of the American Dietetic Association's Dietetic Educators Practice group, Eastman has plans for incorporating Japanese and American nutrition in her future activities. In September she will again team up with Mune to make a presentation at the ADA Food Nutrition Conference Expo. She plans to present a session on Japan-U.S. dietetic collaborations for the same conference in 2007.
Eastman looks forward to her return to Japan in 2008 for the 15th Annual International Congress of Dietetics, where she will meet with dietitians from around the world.

Saturday, July 08, 2006

Claims milk might not be good for us

http://au.news.yahoo.com//060707/23/zow0.html

By 7 News
Adults should not drink milk because we are not designed to digest it, a Melbourne nutritionist has claimed in a new book.
Alternative medicine practitioner Dr Rick Donald said up to 80 per cent of adults do not have the special 'lactose' enzyme required to digest milk.
"Digesting milk and getting the goodness out of the milk, that is the main problem," Dr Donald said.
The dairy industry said the claims were nonsense.
Dairy Farmer Peter Holland said milk was a proven fantastic nutritional product.
"It's just a great product for teeth and bones and it's just everything in moderation," Mr Holland said.
Dairy Australia's chief dietician Dr Malcolm Riley said you would have to eat a bowl of beans, or a large lot of spinach to get the same calcium content of a glass of milk.
"It's a major food group, it's a major source of nutrients for Australians, why should we change?" Dr Riley said.
But Dr Donald said we should reduce our milk intake because we are not eating the way humans are designed to.
"Milk is for cows," Dr Donald said.
He is also turning the 30-year-old food pyramid on its head claiming that we have been wrongly eating too many processed carbohydrates for too long and that half of our diet should be fresh vegetables, fruit and oils.
Alternative theories on what and how we eat certainly provide food for thought, but ultimately it is Food Standards Australia and New Zealand which decides what is safe or not.

Researchers from both the National Institutes of Health and the cosmetics industry are studying folk medicine to come up with new products and treatments.

http://www.physorg.com/news71497613.html


Ancient Chinese medicine is yielding everything from hay fever relief to aiding in vitro fertilization, the Wall Street Journal reported Friday.

According to data from the alternative medicine division of the National Institutes of Health, a 2004 survey showed that more than a third of Americans over 18 use some form of alternative medicine.

"The reality is existing Western medicine can't meet current medical needs," says Edmund Lee, executive director of the Hong Kong Jockey Club Institute of Chinese Medicine which is looking into traditional treatments thanks to a $64 million endowment.

In Vietnam, the government has opened a traditional medicine and pharmacy institute to study both traditional and Western medicines while a government-run Forestry Research Institute in Malaysia is developing health supplements based on the medicine of a local tribe.

Healthcare researchers aren't the only ones interested in traditional medicines.

Cosmetics companies like America's Estée Lauder and Shiseido of Japan have jumped on the bandwagon, incorporating ingredients from Chinese medicine into their cosmetics lines.

Anxious, Depressed People Over 65 Turn More Often to Alternative Therapies

http://www.newswise.com/articles/view/521735/?sc=rsmn

Newswise — People over 65 who are depressed or anxious turn to complementary or alternative medicine more often than older people who are not anxious or depressed – but not to treat their mental symptoms.
Joseph. G. Grzywacz, Ph.D., and colleagues from Wake Forest University School of Medicine reported in the Journal of Alternative and Complementary Medicine that 34.9 percent of people over 65 who had symptoms of anxiety or depression used complementary or alternative medicine (CAM), compared to 26.5 percent of those without mental symptoms.
When praying for health is considered a form of CAM and added in, the percentage jumps to 81.7 percent of those with mental symptoms, compared to 64.6 percent of those without.
But the results showed that fewer than 20 percent of those with anxiety or depression used CAM to treat it. That was a surprise.
“Based on previous research and models of health self management, it was anticipated that CAM use would be greater among older adults with self-reported anxiety or depression than those without such conditions,” said Grzywacz, associate professor of family and community medicine.
The results are based on the 2002 National Health Interview Survey (NHIS) Alternative Health Supplement, which Grzywacz said was “the largest and most representative study of CAM use in the U.S. population to date.” The survey included 30,785 persons who participated in face-to-face interviews with U.S. Census Bureau personnel.
People who answered “yes” to the question “During the past 12 months have you been frequently depressed or anxious?” were defined as having anxiety or depression, he said.
“The findings demonstrate that a significantly greater proportion of older adults with anxiety or depression, in contrast to those without these conditions, use CAM,” said Grzywacz. “These differences are driven by greater use of spiritual practices, relaxation techniques and non-vitamin, non-mineral natural products.”
But he added, “Older adults with anxiety or depression generally do not use CAM to treat their mental conditions.”
He said that the 2002 NHIS survey was the first with sufficient numbers of older adults to provide description of CAM use among those with anxiety and depression.
Grzywacz said that mental disorders among older adults are under-diagnosed and under-treated.
Partly, that’s because people over 65 don’t believe it is treatable. “Older adults frequently report that depressive feelings are a natural part of aging and may not view them as something requiring treatment,” said Grzywacz.
Another surprise was that there was no difference among race or ethnic groups in the use of CAM for poor mental health. Last December, Grzywacz and his team reported that, among people over 65, blacks and Native Americans make much greater use of home remedies than whites. The differences seemed to be based on culture rather than access to health care.
In the current study, he said, “in the absence of conventional treatment, we expected that minority elders would seek other therapies to manage their mental health.” But that didn’t happen.
Other investigators in the study included Thomas A. Arcury, Ph.D., from Family and Community Medicine, and Sara A. Quandt, Ph.D., Ronny A. Bell, Ph.D., Wei Lang, Ph.D., and Cynthia K Suerken, M.S., all from the Division of Public Health Sciences. The research was supported by the National Center for Complementary and Alternative Medicine.
Wake Forest University Baptist Medical Center is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University Health Sciences, which operates the university’s School of Medicine. U.S. News & World Report ranks Wake Forest University School of Medicine 18th in family medicine, 20th in geriatrics, 25th in primary care and 41st in research among the nation's medical schools. It ranks 32nd in research funding by the National Institutes of Health. Almost 150 members of the medical school faculty are listed in Best Doctors in America.

Monday, July 03, 2006

Study Shows Long Term Danger of Mad Cow Disease

Study shows danger of mad cow disease International Herald Tribune - France, Published: June 22, 2006 http://www.iht.com/articles/2006/06/22/news/brain.php
Study shows danger of mad cow disease

LONDON People could be infected with the human form of mad cow disease for more than 50 years without developing the illness, which means the size of a potential epidemic may be underestimated, British scientists said Friday. About 160 people have been diagnosed with variant Creutzfeldt-Jakob disease. Cases of the fatal disease have also been reported in France, Italy, Ireland, the Netherlands, Canada, Japan and the United States.Estimates have varied widely of how many people are likely to develop the brain illness caused by eating meat products contaminated with bovine spongiform encephalopathy, or BSE.It has been difficult to predict due to the long incubation period, which scientists had thought could be up to 20 years.But John Collinge, a professor at University College, London, and researchers believe it could be longer and that an eventual epidemic could be bigger.There could be "substantial underestimations" in recent estimates of the size of the vCJD epidemic, Collinge said in a report in The Lancet medical journal.The scientists' findings are based on a study of another human disease called kuru, which like vCJD is caused by a mutated prion brain protein. Kuru reached epidemic proportions in some parts of Papua New Guinea where cannibalism had been practiced up to the 1950s in a ritual where natives ate dead relatives as a mark of respect.Collinge and his team calculated the minimum incubation period for kuru based on when cannibalism was stopped and the year of birth of the last recorded patient.According to their calculations, the minimum incubation time ranged from 34 to 41 years but in men rose to more than 50 years. They suspect it could be longer for vCJD because the infection was transmitted between species, from cows to humans, which usually takes longer than within the same species.They also identified a genetic variation in the kuru patients that was linked with extended incubation and resistance to prion disease. Patients already diagnosed with vCJD could represent a distinct genetic subgroup of the population with an unusually short incubation period, according to Collinge.The Lancet described the study in an editorial as an innovative piece of research. "Any belief that vCJD incidence has peaked and that we are through the worst of this sinister disease must now be treated with extreme skepticism," it said.Diagnosis in the NetherlandsA second Dutch person has been diagnosed with the human variant of mad cow disease after a 26-year-old Dutch woman died from the disease last year, Dutch health authorities said Thursday, Reuters reported from Amsterdam. The Dutch Institute for Health and Environment said only that the person probably got infected by eating contaminated meat products. The Netherlands is a leading exporter of meat and dairy products.